Publications
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Functional analysis of single enzymes combining programmable molecular circuits with droplet-based microfluidics
The analysis of proteins at the single-molecule level reveals heterogeneous behaviours that are masked in ensemble-averaged techniques. The digital quantification of enzymes traditionally involves the observation and counting of single molecules (...)
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Coupling Exponential to Linear Amplification for Endpoint Quantitative Analysis
Exponential DNA amplification techniques are fundamental in ultrasensitive molecular diagnostics. These systems offer a wide dynamic range, but the quantification requires real-time monitoring of the amplification reaction. Linear amplification (...)
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In Vitro Enzyme Self-Selection Using Molecular Programs
Directed evolution provides a powerful route for in vitro enzyme engineering. State-of-the-art techniques functionally screen up to millions of enzyme variants using high throughput microfluidic sorters, whose operation remains technically (...)
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Dynamical order and many-body correlations in zebrafish show that three is a crowd
Zebrafish constitute a convenient laboratory–based biological system for studying collective behavior. It is possible to interpret a group of zebrafish as a system of interacting agents and to apply methods developed for the analysis of systems (...)
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Odd elasticity and topological waves in active surfaces
Odd elasticity describes active elastic systems whose stress-strain relationship is not compatible with a potential energy. As the requirement of energy conservation is lifted from linear elasticity, new antisymmetric (odd) components appear in (...)
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Noise-induced collective actuation in active solids
Collective actuation describes the spontaneous synchronized oscillations taking place in active solids when the elasto-active feedback, which generically couples the reorientation of the active forces and the elastic stress, is large enough. In (...)
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Does the Larkin length exist?
The yield stress of random solid solutions is a classic theme in physical metallurgy that currently attracts a renewed interest in connection to high entropy alloys. Here, we revisit this subject using a minimal dislocation dynamics model, where (...)
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Martingale drift of Langevin dynamics and classical canonical spin statistics
A martingale is a stochastic process that encodes a kind of fairness or unbiasedness, which is associated with a reference process. Here we show that, if the reference process xt evolves according to the Langevin equation with drift a(x) and if (...)
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Spontaneous self-constraint in active nematic flows
Active processes drive biological dynamics across various scales and include subcellular cytoskeletal remodelling, tissue development in embryogenesis and the population-level expansion of bacterial colonies. In each of these, biological (...)
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Enhanced diffusion of tracer particles in nonreciprocal mixtures
We study the diffusivity of a tagged particle in a binary mixture of Brownian particles with nonreciprocal interactions. Numerical simulations reveal that, for a broad class of interaction potentials, nonreciprocity can significantly increase (...)