Contact :
Hèléne Berthoumieux
helene.berthoumieux (arobase)
Tel : +33 (0) 1 40 79 xx xx

Paddy Royall
paddy.royall (arobase)
Tel : +33 (0) 1 40 79 xx xx


Gulliver seminars take place on Mondays at 11:30 AM in the F304 room, and typically last one hour including questions. The seminars are in English, and the scientific topics are mainly those studied in the laboratory.

Gulliver Seminar : Jean-Loup Faulon (INRAE)

Lundi 20 mars 2023 de 11h30 à 12h30 - Bibliothèque PCT - F3.04

In vitro and in vivo neural computations with metabolism

Engineering information processing devices in living systems is a long-standing venture of synthetic biology. Yet, the problem of engineering devices that perform basic operations found in machine learning remains largely unexplored. I will first present the in vitro (cell-free) engineering of enzyme catalyzed perceptrons. The performances of the perceptrons will be exemplified with biological samples classification based on their metabolic, protein and RNA compositions. With the goal of engineering in vivo learning devices, I will next show how hybrid mechanistic-neural models can perfectly surrogate classical constraint-based modelling, and make metabolic networks suitable for backpropagation and consequently be used as an architecture for machine learning. The performance of the hybrid models, trained with experimental datasets of E. coli growth rates in different media composition and different gene knockouts, will be showcased on cross-validation sets.


Seminars  (1)

  • Gulliver Seminar
    Lundi 3 juin de 11h30 à 12h30 - C162
    Soft nanofluidics with wetting films and soap bubbles
    Anne-Laure Biance Water and salt transports through nanoporous membranes are encountered in many applications, from desalination, filtration or energy harvesting membranes. In this talk, we will investigate the particular nature of ionic and liquid transports at the nanoscale, focusing in particular on (...)
General recommendations for the speakers

The audience is often heterogeneous - because of the wide range of scientific topics covered in the lab - so planning a talk for a broader audience would be preferred. The seminar is in English, and speakers are thus invited to prepare their slides in English.

The seminar starts at 11:30 AM. The speaker is asked to arrive in the lab at least 15 minutes in advance to set up their computer. The talks last typically 45 minutes, and are followed by a discussion time.