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Seminars
Contact :
Hèléne Berthoumieux
Tel : +33 (0) 1 40 79 xx xx
Paddy Royall
Tel : +33 (0) 1 40 79 xx xx
Gulliver seminars take place on Mondays at 11:30 AM in the F304 room, and typically last one hour including questions. The seminars are in English, and the scientific topics are mainly those studied in the laboratory.
Gulliver Seminar : Ivan Junier
Topology matters in (active) bacteria
DNA is a polymer composed of nucleotides, arranged in a double-helix structure formed by two intertwined strands. This helical structure imposes topological constraints that impact fundamental processes in all living organisms, such as DNA replication and gene expression. As a result, in all cells, specialized enzymes known as topoisomerases modulate the topological properties of DNA, resolving problems related to molecular entanglement and torsional stress.
In this talk, I will present our recent work on extracting quantitative insights into the operational modes and activities of topoisomerases involved in gene transcription, the initial stage of gene expression. The talk aims to be didactic, providing a step-by-step and comprehensive explanation of all the relevant (biological) processes we seek to rationalize. One of the goals is to demonstrate how a physics-based approach, combining reductionist experiments and first-principle biophysical modeling, provides a promising avenue for deciphering the complexity underlying the regulation of gene expression in bacteria.
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The audience is often heterogeneous - because of the wide range of scientific topics covered in the lab - so planning a talk for a broader audience would be preferred. The seminar is in English, and speakers are thus invited to prepare their slides in English.
The seminar starts at 11:30 AM. The speaker is asked to arrive in the lab at least 15 minutes in advance to set up their computer. The talks last typically 45 minutes, and are followed by a discussion time.