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Seminars
Contact :
Hèléne Berthoumieux
Tel : +33 (0) 1 40 79 xx xx
Paddy Royall
Tel : +33 (0) 1 40 79 xx xx
Gulliver seminars take place on Mondays at 11:30 AM in the F304 room, and typically last one hour including questions. The seminars are in English, and the scientific topics are mainly those studied in the laboratory.
Gulliver Seminar : Yann Chalopin (Centrale-Supélec)
Localisation of thermal energy, topological disorder and the art of regulation in biochemistry
This seminar proposes to address an atomic mechanism describing how part of the regulation of biochemistry emerges in proteins and protein assemblies. A physical description linking the topology of macromolecular complexes to their biochemical function will be exposed through dynamic effects arising from fold-encoded localized phonons. We thus show that irregular macromolecules intrinsically possess information or entropy transport networks involving distinct molecular domains. These evolutionarily driven distal feedbacks between atomic fluctuations explain the basis of three of the most fundamental functions of proteins, namely catalysis, transmembrane communication, and the inhibitory effects of drug molecules. This theoretical approach provides a microscopic understanding of how nature exploits structural disorder to produce molecules with fold-encoded biochemical complexity, thus providing a new tool for controlling protein and nucleoprotein complexes in general.
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Seminars (2)
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Gulliver Seminar : Haim Diamant (Tel Aviv University)
Lundi 29 avril de 11h30 à 12h30 - C162
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Gulliver seminar : Matthew Turner
Lundi 13 mai de 11h30 à 12h30 - C162
The audience is often heterogeneous - because of the wide range of scientific topics covered in the lab - so planning a talk for a broader audience would be preferred. The seminar is in English, and speakers are thus invited to prepare their slides in English.
The seminar starts at 11:30 AM. The speaker is asked to arrive in the lab at least 15 minutes in advance to set up their computer. The talks last typically 45 minutes, and are followed by a discussion time.